Mechanisms for the Sex-Specific Effect of H. Pylori on Risk of Gastroesophageal Reflux Disease and Barrett’s Esophagus

SE Wang; SG Dashti; AM Hodge; SC Dixon-Suen; N Castaño-Rodríguez; RJS Thomas; GG Giles; RL Milne; A Boussioutas; BJ Kendall; DR English

Journal article

Mechanisms for the Sex-Specific Effect of H. Pylori on Risk of Gastroesophageal Reflux Disease and Barrett’s Esophagus

SE Wang, SG Dashti, AM Hodge, SC Dixon-Suen, N Castaño-Rodríguez, RJS Thomas, GG Giles, RL Milne, A Boussioutas, BJ Kendall, DR English

Cancer Epidemiology Biomarkers and Prevention | Published : 2022

DOI: 10.1158/1055-9965.EPI-22-0234

Abstract

Background: Mechanisms for how Helicobacter pylori infection respectively. No association was observed for women. H. pylori-affects risk of gastroesophageal reflux disease (GERD) and Barrett’s induced atrophic antral gastritis was more common in men (68%) esophagus are incompletely understood and might differ by sex. than in women (56%; P ¼ 0.015). For men, 5 of the 15 per 1,000 Methods: In a case–control study nested in the Melbourne excess Barrett’s esophagus risk from being seronegative were mediCollaborative Cohort Study with 425 GERD cases and 169 Barrett’s ated by GERD. esophagus cases (identified at 2007–2010 follow-up), we estimated Conclusions: Men, but not women, who were H. pylori..

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University of Melbourne Researchers

Ghazaleh Dashti Author

Allison Hodge Author

Robert Thomas Author

Graham Giles Author

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Funding Acknowledgements

We thank David Whiteman for assistance with developing the questionnaire. The Melbourne Collaborative Cohort Study cohort recruitment was funded by VicHealth and Cancer Council Victoria. The Melbourne Collaborative Cohort Study was further augmented by Australian National Health and Medical Research Council grants 209057, 396414, and 1074383 and by infrastructure provided by Cancer Council Victoria. Cancer cases and vital status of participants were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. The study of gastroesophageal reflux and Barrett?s Esophagus was funded by an NHMRC project grant (504708) . S.E. Wang is supported by an Australian Government Research Training Program Scholarship. S.C. Dixon-Suen is supported by an Alfred Deakin Postdoctoral Research Fellowship from Deakin University. N. Castan~o-Rodr?guez is supported by a Cancer Institute NSW Early Career Fellowship (2019/ECF1082) and a UNSW Scientia Fellowship.